At the beginning of my work at the Institute of Endocrinology, while still a junior researcher, my primary focus was on studying the consequences of the 1986 Chornobyl disaster, specifically benign neoplasms in children. At that time, most researchers preferred studying malignant neoplasms. There were indeed many of them, and they undoubtedly pose a greater threat. However, the scientific analysis of benign pathology in children was poorly studied at the time. Under the guidance of experienced mentors, to whom I am still grateful for their help and support (the head of the surgical department Ihor Vasylovych Komisarenko and the head of the morphological laboratory Tetiana Ivanivna Bohdanova), my Candidate of Medical Sciences dissertation "Morphological diagnostics and surgical treatment of benign thyroid neoplasms in children and adolescents" was completed and successfully defended in 2001.
Practical surgical activity combined with research activity, particularly regarding thyroid pathology, led to a new direction in my research: the development and implementation of effective mechanisms for storing and analyzing medical data. Along this path, the TherDep medical information system was developed, which eventually became the patient registry for the institute's clinic and polyclinic and remains in operation today, assisting doctors in their clinical work and scientists in their research. Today, this registry contains information on over 450,000 outpatient records of our patients. Under my supervision, two independent research themes were completed at the Institute at the intersection of two disciplines: endocrinology and medical informatics. My Doctor of Medical Sciences dissertation, titled "Information mapping of the diagnostic and treatment process in an endocrinology clinic," was completed in these two specialties and successfully defended in 2008.
Subsequently, my scientific interests expanded to cover the entire spectrum of surgical endocrine pathology managed by the department. Among certain specific directions, I can highlight the analysis of long-term treatment outcomes (primarily based on the established electronic patient registry) and the analysis of the implementation of minimally invasive and endoscopic techniques. However, these are only the main directions. For instance, at one time, a hypothesis was proposed regarding the effect of suppressive thyroxine therapy in highly differentiated thyroid carcinomas. According to this hypothesis, supranormal (suppressive) doses of thyroxine cannot reverse the oncological process but only reduce the rate of growth and metastasis. Thus, it prolongs the existence of tumor foci until they are detected. Therefore, when observing patients, suppressive therapy most often has dubious benefits, yet it remains in international guidelines. This hypothesis (this approach) has its supporters worldwide, but in Ukraine, it still sounds quite new and unusual to many endocrinologists.